General Information

  • ID:  hor002474
  • Uniprot ID:  NA
  • Protein name:  Antho-RWamide II
  • Gene name:  NA
  • Organism:  Calliactis parasitica
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EGLRW
  • Length:  5
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T5 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Evoked contractions of body wall muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002474_AF2.pdbhor002474_ESM.pdb

Physical Information

Mass: 73127 Formula: C30H45N9O8
Absent amino acids: ACDFHIKMNPQSTVY Common amino acids: EGLRW
pI: 6.41 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -110 Boman Index: -1354
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 16108 Extinction Coefficient cystines: 5500
Absorbance 280nm: 1375

Literature

  • PubMed ID:  1675657
  • Title:  Effects of Three Anthozoan Neuropeptides, Antho-RWamide I, Antho-RWamide II and Antho-RFamide, on Slow Muscles From Sea Anemones